Click Chemistry Tools產(chǎn)品Alkynyl Palmitic Acid說(shuō)明書

Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry。

炔基肉豆蔻酸可用于鑒定和表征翻譯后肉豆蔻酸的炔基棕櫚酸（15-十六烷酸或棕櫚酸（15-炔））是一種具有ω末端炔烴的改性棕櫚酸。炔基棕櫚酸常用于使用強(qiáng)大的點(diǎn)擊化學(xué)來(lái)鑒定和表征蛋白質(zhì)的翻譯后S-棕櫚酰化。

Alkynyl Palmitic Acid (Alk-C16) 是一種 PROTAC linker，屬于 alkyl chain 類。可用于合成 PROTAC 分子。Alkynyl Palmitic Acid 是一種點(diǎn)擊化學(xué)試劑。它含有 Alkyne 基團(tuán)，可以和含有 Azide 基團(tuán)的分子發(fā)生銅催化的疊氮-炔環(huán)加成反應(yīng) (CuAAc)。

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Selected References參考文獻(xiàn)

1. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107.

2. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890.

3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res .

4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501.